Born in Brussels, Marc-Henri Wajnberg studied film at INSAS, the National Institute of Performing Arts and Broadcasting Techniques.

His first documentary, made after graduating from INSAS, Heureux comme un bébé dans l'eau (Happy as a Baby in Water), a film about non-violent motherhood, remained in theaters in Belgium and France for several months.

Marc-Henri Wajnberg founded Wajnbrosse Productions with his brother Alexandre Wajnberg in 1983, the year in which he wrote, directed, starred in, and produced the highly acclaimed Claps series: 1,200 eight-second shorts. They were broadcast daily for several years in more than 50 countries.

Rich in ideas and new concepts, he produced a multitude of audiovisual creations.
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In 1993, he co-wrote, directed, and produced his first feature film, Just Friends, which represented Belgium at the Oscars.  The film immerses us in the jazz music scene in Antwerp in 1959, through the eyes of a talented saxophonist dreaming of a career in New York. It won over critics with its aesthetic research and the performances of its actors (Josse de Pauw, Sylvia Milhaud, Ann Gisel Glass, Charles Berling).
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His short film Le Réveil (1996), which won awards at Cannes and 22 international festivals, features a masterful Jean-Claude Dreyfus waking up every morning using a thousand ingenious mechanisms.
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His curiosity and interest in art and history also led him to devote himself to making creative documentaries, such as Evgueni Khaldei, photographe sous Staline (Evgueni Khaldei, Photographer under Stalin) in 1997, in which he meets this moving war photographer, the Soviet Capa, author of the iconic photo of the end of World War II showing a soldier carrying the Soviet flag on a burning Reichstag.

In 2001, he co-wrote, directed, and produced Oscar Niemeyer, an architect committed to the century, a testimony to the work and fight against dictatorship of the architect of Brasilia.

During the 2000s, he designed and produced a collection of 33 documentaries for Arte, Kaléidoscope, regards sur un cadre de vie (Kaleidoscope, perspectives on a living environment), of which he directed four episodes. In each episode, Kaléidoscope – le guide – chooses a unique living space, public or private, in Europe or elsewhere, and presents it through a series of fragmented perspectives.
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He collaborated on the development and co-produced The Five Obstructions (2003), a feature-length documentary by Lars von Trier and Joergen Leth. A research film in which the preconceived ideas and opinions of the two men are continually challenged.
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From 2009 to 2023, he worked between the DRC and Belgium, directing and producing films showing the tragic situation of street children in Kinshasa.
From this encounter with Kinshasa and its inhabitants, he created Kinshasa Kids. A fictional film with a documentary style, it tells the story of eight street children in search of a better life in the bustling city of Kinshasa. Invited to more than 60 festivals (Venice, Toronto, Pusan, New York, etc.), Kinshasa Kids has received eight international awards, including the Human Rights Award in Strasbourg and the Magritte Award for Best Editing.
He continues his work to raise awareness of children's rights. He writes, directs, and produces an interactive virtual reality film with street children in Kinshasa: Kinshasa Now. The film is selected for the VR Expanded competition at the 77th Venice Film Festival as well as 52 other festivals and wins eight awards.

After various film production experiences in Kinshasa, including documentaries, web films, concert recordings, CD productions, and virtual reality films, Marc-Henri Wajnberg wrote, directed, and produced the feature-length documentary I am Chance in 2022, capturing the turbulent lives of a group of young girls living on the streets of Kinshasa (41 festivals and 14 awards).

For all the children who appear in his films, he contributes as much as he can to their care, integrating them into centers and rebuilding family ties. He helps finance their education so that they can learn to read and write.

He is currently developing PROUT, a stop-motion plasticine series (52 x 7'), the pilot of which is in post-production. PROUT received the award for best concept in a competition organized by the Association des Scénaristes, the Centre du Cinéma de la FWB, the SACD, and the SABAM.

His films have won over 100 international awards.